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HelpTest ID NBLD0073 Metanephrines, Fractionated, 24 Hour, Urine
Useful For
A first- and second-order screening test for the presumptive diagnosis of catecholamine-secreting pheochromocytomas and paragangliomas
Confirming positive plasma metanephrine results
Specimen Type
UrineOrdering Guidance
Necessary Information
24-Hour volume (in milliliters) is required.
Specimen Required
Patient Preparation: Tricyclic antidepressants, labetalol, and sotalol medications may elevate levels of metanephrines producing results that cannot be interpreted. If clinically feasible, it is optimal to discontinue these medications at least 1 week before collection. For advice on assessing the risk of removing patients from these medications and alternatives, consider consultation with a specialist in endocrinology or hypertension.
Supplies: Urine Tubes, 10 mL (T068)
Container/Tube: Plastic urine tube
Specimen Volume: 10 mL
Collection Instructions:
1. Add 10 g (pediatric: 3 g) of boric acid or 25 mL (pediatric: 15 mL) of 50% acetic acid as preservative at start of collection.
2. Collect urine for 24 hours.
Additional Information: See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens for multiple collections.
If preservative is not available at your facility, the specimen should be kept refrigerated during collection and an aliquot should be submitted frozen to Sanford Laboratories in Sioux Falls.
Record the total volume on the specimen and/or requisition if applicable.
24-Hour Urine Collection Instructions English
24-Hour Urine Collection Instructions Spanish
Reject Due To
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.Specimen Minimum Volume
3 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Urine | Refrigerated (preferred) | 28 days | |
| Ambient | 28 days | ||
| Frozen | 28 days |
Day(s) Performed
Monday through Friday
Report Available
3 to 5 daysMethod Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Performing Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
83835
Reporting Name
Metanephrines, Fractionated, 24h, UReference Values
METANEPHRINE
Males
Normotensives
3-8 years: 29-92 mcg/24 h
9-12 years: 59-188 mcg/24 h
13-17 years: 69-221 mcg/24 h
≥18 years: 44-261 mcg/24 h
Reference values have not been established for patients that are younger than 36 months.
Hypertensives: <400 mcg/24 h
Females
Normotensives
3-8 years: 18-144 mcg/24 h
9-12 years: 43-122 mcg/24 h
13-17 years: 33-185 mcg/24 h
≥18 years: 30-180 mcg/24 h
Reference values have not been established for patients that are younger than 36 months.
Hypertensives: <400 mcg/24 h
NORMETANEPHRINE
Males
Normotensives
3-8 years: 34-169 mcg/24 h
9-12 years: 84-422 mcg/24 h
13-17 years: 91-456 mcg/24 h
18-29 years: 103-390 mcg/24 h
30-39 years: 111-419 mcg/24 h
40-49 years: 119-451 mcg/24 h
50-59 years: 128-484 mcg/24 h
60-69 years: 138-521 mcg/24 h
≥70 years: 148-560 mcg/24 h
Reference values have not been established for patients that are younger than 36 months.
Hypertensives: <900 mcg/24 h
Females
Normotensives
3-8 years: 29-145 mcg/24 h
9-12 years: 55-277 mcg/24 h
13-17 years: 57-286 mcg/24 h
18-29 years: 103-390 mcg/24 h
30-39 years: 111-419 mcg/24 h
40-49 years: 119-451 mcg/24 h
50-59 years: 128-484 mcg/24 h
60-69 years: 138-521 mcg/24 h
≥70 years: 148-560 mcg/24 h
Reference values have not been established for patients that are younger than 36 months.
Hypertensives: <900 mcg/24 h
TOTAL METANEPHRINE
Males
Normotensives
3-8 years: 47-223 mcg/24 h
9-12 years: 201-528 mcg/24 h
13-17 years: 120-603 mcg/24 h
18-29 years: 190-583 mcg/24 h
30-39 years: 200-614 mcg/24 h
40-49 years: 211-646 mcg/24 h
50-59 years: 222-680 mcg/24 h
60-69 years: 233-716 mcg/24 h
≥70 years: 246-753 mcg/24 h
Reference values have not been established for patients that are younger than 36 months.
Hypertensives: <1,300 mcg/24 h
Females
Normotensives
3-8 years: 57-210 mcg/24 h
9-12 years: 107-394 mcg/24 h
13-17 years: 113-414 mcg/24 h
18-29 years: 142-510 mcg/24 h
30-39 years: 149-535 mcg/24 h
40-49 years: 156-561 mcg/24 h
50-59 years: 164-555 mcg/24 h
60-69 years: 171-616 mcg/24 h
≥70 years: 180-646 mcg/24 h
Reference values have not been established for patients that are younger than 36 months.
Hypertensives: <1,300 mcg/24 h
For International System of Units (SI) conversion for Reference Values, see www.mayocliniclabs.com/order-tests/si-unit-conversion.html
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.Forms
If not ordering electronically, complete, print, and send an Oncology Test Request (T729) with the specimen.
Special Instructions
Secondary ID
83006SANFORD LABORATORY INTERFACE BUILD INFORMATION
| Result Code | Result Code Description |
|---|---|
| 6461 | Volume 24 Hour Urine (ml) |
| 2698 | Metanephrine 24 Hour Urine |
| 2896 | Normetanephrine 24 Hour Urine |
| 2696 | Metanephrine Total 24 Hour Urine |
| 16972 | Collection Duration (h) |
| 16973 | Comment |