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Test ID NBLD0708 Porphyrins, Quantitative, Random, Urine

Reporting Name

Porphyrins, QN, Random, U

Useful For

Preferred test to begin assessment for congenital erythropoietic porphyria and porphyria cutanea tarda and during symptomatic periods for acute intermittent porphyria, hereditary coproporphyria, and variegate porphyria when specimen transport will not exceed 72 hours

 

This test is not useful for the diagnosis of conjugated or unconjugated hyperbilirubinemia syndromes such as Dubin Johnson syndrome or Rotor syndrome.

Testing Algorithm

The following algorithms are available:

-Porphyria (Acute) Testing Algorithm

-Porphyria (Cutaneous) Testing Algorithm

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Urine


Ordering Guidance


This random urine test should be ordered when the specimen will be received at Mayo Clinic Laboratories within 72 hours. If transportation may take longer than 72 hours, order both PQNU / Porphyrins, Quantitative, 24 Hour, Urine and ALAUR / Aminolevulinic Acid, Urine and follow collection guidelines.



Shipping Instructions


Ship specimen in amber bottle to protect from light.



Necessary Information


Include a list of medications the patient is currently taking.



Specimen Required


Patient Preparation: For at least 24 hours before specimen collection, patient must not consume any alcohol.

Supplies: Urine Container - Amber, 60 mL (T596)

Container/Tube: 60-mL Amber urine container

Specimen Volume: 20 to 50 mL

Collection Instructions:

1. Collect a random urine specimen.

2. No preservative3. Specimens should be protected from light and frozen immediately following collection.


Specimen Minimum Volume

15 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Frozen 72 hours LIGHT PROTECTED

Reference Values

Uroporphyrin, Octa: ≤3.1 mcmol/mol creatinine

Heptacarboxylporphyrins: ≤0.9 mcmol/mol creatinine

Hexacarboxylporphyrins: ≤0.3 mcmol/mol creatinine

Pentacarboxylporphyrins: ≤1.2 mcmol/mol creatinine

Coproporphyrin, Tetra: ≤25.0 mcmol/mol creatinine

Porphobilinogen: ≤0.2 mmol/mol creatinine

Aminolevulinic Acid: ≤ 2.3 mmol/mol creatinine

Day(s) Performed

Monday through Friday

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

84110-Porphobilinogen, quantitative

84120-Porphyrins, quantitation and fractionation

82135- ALA Delta Random Urine

Report Available

2 to 4 days

Reject Due To

  All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Method Name

High-Performance Liquid Chromatography (HPLC) with Fluorometric Detection/Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

Secondary ID

60597
Sanford Laboratories - Enterprise Additional Information:

SANFORD LABORATORY INTERFACE BUILD INFORMATION

 Result Code     Result Code Description   
 28373  Uroporphyrin, Octa
 28374  Heptacarboxylporphyrins
 28375  Hexacarboxylporphyrins
 28376  Pentacarboxylporphyrins
 28377  Coproporphyrin, Tetra
 28378  Porphobilinogen
 29374  Aminolevulinic Acid, U
 28379  Interpretation
 29375  Reviewed By