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Test ID NBLD0523 Panel for Prion Markers, CSF 

Additional Codes

Alias:  14-3-3 Protein, CSF (Prion Disease)

Specimen Type/Requirements

Sterile Container - CSF

 

Collect CSF by lumbar puncture.  Discard first 2 mL that flows from tap.  Collect next 5 mL CSF, avoiding a bloody tap.  Freeze within 20 minutes of collection.  Store and transport frozen.  Ship using styrofoam container with sufficient dry ice (5 lbs/24 hours).  The National Prion Disease Pathology Surveillance Center requests a urine sample for research purposes with all CSF samples if available.  

Note:  Patient must be 12 years of age or older for this test to be performed.

Reject Criteria:  Bloody and insufficient sample quantity; samples that are colored or contain blood cannot be performed.

 

Test is affected by hemolysis.  Test is not affected by lipemia.

Specimen Volume

 Preferred Volume     2 mL CSF   
 Minimum Volume     1 mL CSF   

 

Stability/Transport

 Room Temperature     Not Acceptable     
 Refrigerated     Not Acceptable     
 Frozen     Indefinitely     Preferred for transport   

 

Performed Test Frequency

Varies

Report Available

7 days

Methodology

Immunoassay, RT-QuIC

Performing Lab

Quest Chantilly forwards to National Prion Disease Pathology Surveillance Center

CPT

0035U, 86317x2

Interface Build Information

SANFORD LABORATORY INTERFACE BUILD INFORMATION

 Result Code    Result Code Description   
 28100  Specimen Condition
 25999  RT-QUIC (CSF)*
 26000  T-TAU PROTEIN (CSF)++
 26001  14-3-3 GAMMA (CSF)++
 25998  LIKELIHOOD OF PRION DISEASE   
 28101  REVIEWED AND APPROVED BY