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HelpTest ID LBAN0023 Postmortem Screening, Bile and Blood Spot
Useful For
Postmortem evaluation of individuals at any age who died suddenly or unexpectedly; testing is particularly recommended under the following circumstances (risk factors):
-Family history of sudden infant death syndrome or other sudden unexpected deaths at any age
-Family history of Reye syndrome
-Maternal complications of pregnancy (acute fatty liver pregnancy, HELLP syndrome [hemolysis, elevated liver enzymes, and low platelet count])
-Lethargy, vomiting, fasting in the 48 hours prior to death
-Allegation of child abuse (excluding obvious cases of trauma, physical harm)
Macroscopic findings at autopsy:
-Fatty infiltration of the liver
-Dilated or hypertrophic cardiomyopathy
-Autopsy evidence of infection that routinely would not represent a life-threatening event
Specimen Type
Whole bloodNecessary Information
Request the original newborn screening card from the state laboratory where the decedent was born. See Request for Original Newborn Screening Card. Provide patient name, date and time of birth and death, suspected cause of death, circumstances of death, relevant family history, and date and time of sample collection.
Biochemical Genetics Patient Information (T602) is recommended, but not required, to be filled out and sent with the specimen to aid in the interpretation of test results.
Specimen Required
Both bile and blood spots are required.
Supplies: Card-Postmortem Screening (Filter Paper) (T525)
Container/Tube:
Preferred: Card-Postmortem Screening Card (Filter Paper)
Acceptable: Whatman Protein Saver 903 paper or local newborn screening card
Specimen Volume: Properly completed screening card
Collection Instructions:
1. Collect blood in a heparin-containing tube and drop 25 mcL of blood onto the 2 circles labeled Blood.
2. Collect bile by direct puncture of the gallbladder and drop 25 mcL of bile onto the 2 circles labeled Bile.
3. Allow to dry at ambient temperature in a horizontal position for a minimum of 3 hours.
4. Fill out information on page 2 of collection card.
5. Do not expose specimen to heat or direct sunlight.
6. Do not stack wet specimens.
7. Keep specimen dry.
Reject Due To
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.Specimen Minimum Volume
Bile spot: 1; Blood spot: 1
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Whole blood | Ambient (preferred) | FILTER PAPER | |
| Frozen | FILTER PAPER | ||
| Refrigerated | FILTER PAPER | ||
Day(s) Performed
Wednesday
Report Available
7 to 16 daysMethod Name
Flow Injection Analysis-Tandem Mass Spectrometry (FIA-MS/MS)
Performing Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
83789
Reporting Name
Postmortem ScreeningReference Values
Quantitative results are compared to a constantly updated range which corresponds to the 5 to 95 percentile interval of all postmortem cases analyzed in our laboratory.
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.Forms
If not ordering electronically, complete, print, and send a Biochemical Genetics Test Request (T798) with the specimen.
Special Instructions
Testing Algorithm
For more information see Postmortem Screening Algorithm for Fatty Acid Oxidation Disorders and Organic Acidurias.
Secondary ID
81931SANFORD LABORATORY INTERFACE BUILD INFORMATION
| Result Code | Result Code Description |
|---|---|
| 20798 | Specimen |
| 20799 | Specimen ID |
| 20800 | Source |
| 20801 | Order Date |
| 20802 | Reason for Referral |
| 20803 | Method |
| 20804 | Results |
| 20805 | Interpretation |
| 20806 | Amendment |
| 20807 | Reviewed By |
| 20808 | Release Date |