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Test ID BLOD1551 Diabetes Mellitus Type 1 Evaluation, Serum

Important Note

Effective 2-19-2025:  Due to supply chain issues test results may be delayed. Specimens will be stabilized upon arrival and testing performed when issues are resolved. The duration of this delay is anticipated to be approximately 7-14 days. Notification will be sent when posted turnaround time resumes.

Useful For

Distinguishing type 1 from type 2 diabetes mellitus

 

Identifying individuals at risk of type 1 diabetes (including high-risk relatives of patients with diabetes)

 

Predicting future insulin requirement treatment in patients with adult-onset diabetes

Specimen Type

Serum


Specimen Required


Collection Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 4 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Specimen Minimum Volume

2 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  72 hours

Day(s) Performed

GAD65 antibody: Monday through Friday

Insulin antibodies: Monday, Wednesday, Friday

IA-2 antibody, Zinc Transporter 8 Antibody: Tuesday, Thursday

Report Available

7 to 10 days

Method Name

GD65S, INAB, IA2: Radioimmunoassay (RIA)

EZNT8: Enzyme-Linked Immunosorbent Assay (ELISA)

DMEI: Interpretive Comments

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

86337

86341 x3

Reporting Name

Diabetes Mellitus Type 1 Evaluation

Reference Values

GLUTAMIC ACID DECARBOXYLASE (GAD65) ANTIBODY

≤0.02 nmol/L

Reference values apply to all ages.

 

INSULIN ANTIBODIES

≤0.02 nmol/L

Reference values apply to all ages.

 

ISLET ANTIGEN 2 (IA-2) ANTIBODY

≤0.02 nmol/L

Reference values apply to all ages.

 

ZINC TRANSPORTER 8 (ZnT8) ANTIBODY

< 15.0 U/mL

Reference values apply to all ages.

Test Classification

See Individual Test IDs

Secondary ID

48400

Profile Information

Test ID Reporting Name Available Separately Always Performed
DMEI Diabetes Interpretation, S No Yes
GD65S GAD65 Ab Assay, S Yes Yes
INAB Insulin Abs, S Yes Yes
IA2 IA-2 Ab, S Yes Yes
EZNT8 ZnT8 Ab, S Yes Yes
Sanford Laboratories - Sioux Falls/Rapid City Additional Information:

SANFORD LABORATORY INTERFACE BUILD INFORMATION

Result Code  Result Code Description 
22514 Diabetes Interpretation, S 
13685 GAD65 Ab Assay, S
13064 Insulin Abs, S
17064 IA-2 Ab, S
22504 ZNT8 Ab, S