Test ID BLOD1452 Thyroglobulin, Tumor Marker Reflex, Serum

Important Note

Effective 3/28/2025: Due to assay issues impacting potential reflex component TGMS: Thyroglobulin, Mass Spec., S, results will be delayed past the published turnaround time. Specimens will be stabilized upon arrival and processed in the order they are received. Specimens may take up to 14 days to result and the duration of the delay is expected to last up to 30 days or more. An update will be provided when standard testing resumes.

Useful For

Reporting of accurate thyroglobulin results, depending on the antithyroglobulin antibodies status of the patient

Accurate measurement of serum thyroglobulin in patients with known or suspected antithyroglobulin autoantibodies or possible heterophile antibodies

Specimen Type

Serum Red

Specimen Required

Patient Preparation: For 12 hours before specimen collection, patient should not take multivitamins or dietary supplements (eg, hair, skin, and nail supplements) containing biotin (vitamin B7).

Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube:

Preferred: Red top

Acceptable: None (serum gel/SST are not acceptable)

Submission Container/Tube: Plastic vial

Specimen Volume: 2 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.

Reject Due To

Gross hemolysis	Reject
Gross lipemia	OK
Gross icterus	Reject

Specimen Minimum Volume

1.25 mL

Specimen Stability Information

Specimen Type	Temperature	Time
Serum Red	Refrigerated (preferred)	7 days
	Frozen	30 days
	Ambient	72 hours

Day(s) Performed

Monday through Saturday

Report Available

1 to 6 days

Method Name

HTGT: Immunoenzymatic Assay

TGMS: Tryptic Protein Fragmentation, purified with Immunocapture, Analysis by Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) (This service is performed pursuant to an agreement with SISCAPA Assay Technologies Inc. covering US Patent 7,632,686)

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

86800

84432 (if appropriate)

Reporting Name

Thyroglobulin Reflex to MS or IA

Reference Values

THYROGLOBULIN ANTIBODY

<1.8 IU/mL

THYROGLOBULIN, TUMOR MARKER

≤33 ng/mL

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

Forms

If not ordering electronically, complete, print, and send an Oncology Test Request (T729) with the specimen.

Testing Algorithm

This test begins with the analysis of thyroglobulin antibody by immunoassay. If the thyroglobulin antibody result is negative (<1.8 IU/mL), then thyroglobulin testing will be performed by immunoassay.

If the thyroglobulin antibody result is positive (≥1.8 IU/mL), then thyroglobulin testing will be performed by mass spectrometry.

Reflex Tests

Test ID	Reporting Name	Available Separately	Always Performed
HTGT	Thyroglobulin, Tumor Marker, IA, S	No	No
TGMS	Thyroglobulin, Mass Spec., S	Yes	No

Secondary ID

62936

Sanford Laboratories - Sioux Falls/Rapid City Additional Information:

SANFORD LABORATORY INTERFACE BUILD INFORMATION

Result Code	Result Code Description
19794	Thyroglobulin Antibody, S

Sanford Laboratories - Sioux Falls/Rapid City powered by Mayo Clinic Laboratories

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