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Test ID BLOD0060 Chromium, Serum

Useful For

Screening for occupational exposure

 

Monitoring metallic prosthetic implant wear

Specimen Type

Serum


Ordering Guidance


The US Food and Drug Administration recommended test for monitoring chromium in patients with metal-on-metal implants is CRWB / Chromium, Blood.



Specimen Required


Patient Preparation: High concentrations of gadolinium and iodine are known to potentially interfere with most inductively coupled plasma mass spectrometry-based metal tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.

Supplies:

-Metal Free B-D Tube (No Additive), 6 mL (T184)

-Metal Free Specimen Vial (T173)

Collection Container/Tube: 6 mL Plain, royal blue-top Vacutainer plastic trace element blood collection tube

Submission Container/Tube: 7-mL Mayo metal-free, screw-capped, polypropylene vial

Specimen Volume: 1.6 mL

Collection Instructions: See Metals Analysis Specimen Collection and Transport for complete instructions.


Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Specimen Minimum Volume

0.3 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 28 days METAL FREE
  Ambient  28 days METAL FREE
  Frozen  28 days METAL FREE

Day(s) Performed

Monday through Friday

Report Available

1 to 4 days

Method Name

Triple-Quadrupole Inductively Coupled Plasma-Mass Spectrometry (ICP-MS/MS)

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

82495

Reporting Name

Chromium, S

Reference Values

<0.4 ng/mL

 

When collected by a phlebotomist experienced in ultra-clean collection technique and handled according to the instructions in Metals Analysis Specimen Collection and Transport, we have observed the concentration of chromium in serum to be below 0.4 ng/mL. However, the majority of specimens submitted for analysis from unexposed individuals contain 0.1 ng/mL to 0.3 ng/mL of chromium. Commercial evacuated blood collection tubes not designed for trace-metal specimen collection yield serum containing 2.0 ng/mL to 5.0 ng/mL chromium derived from the collection tube.

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

Secondary ID

8638
Sanford Laboratories - Enterprise Additional Information:

SANFORD INTERFACE BUILD INFORMATION

Result Code  Result Code Description 
20 Chromium