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Test ID NBLD0150 HMA & VMA Urine

Useful For

This test is used in the diagnosis and monitoring of treatment of neuroblastoma and pheochromocytoma.

AKA

Homovanillic Acid

Vanilylmandelic Acid

Specimen Type/Requirements

Urine, Random or 24 Hour submitted in sterile specimen container

Urine absorbed onto filter paper

 

If using filter paper to obtain collection, obtain filter paper urine collection kit from the laboratory. The kit includes one 10 x 10 cm absorbent filter paper, patient identification form and directions for specimen collection. Collect as follows:

  • In young infants, collect from a thoroughly wet diaper not contaminated with stool. Remove top layer of diaper if disposable type. Place filter onto diaper and place diaper on flat hard surface. Place filter paper between two wet portions of diaper and press with fingertips until the filter becomes wet. Do this until the entire filter is damp (filter will look darker).
  • Ultra absorbency diapers may present a problem in collecting enough urine and are not recommended for this collection. If ultra absorbency diapers are used, place several cotton balls between the diaper and baby's genitals. The urine in the cotton ball can the be squeezed onto the filter paper.
  • In toilet trained children, collect 5 ml urine.

Place filter paper on top of plastic bag or a clean non-absorbent surface and let filter paper dry. Label filter paper with patient name and Date of Birth and Collection in pencil ( do not use ink). Place dried filter paper and identification form in a plastic leakproof bag.

Specimen Volume

 

Preferred Volume   5.0 mL  
Minimum Volume   2.0 mL  

 

Stability/Transport

Room Temperature - Urine   not acceptable    
Refrigerated - Urine acceptable   preferred for transport  
Frozen - Urine acceptable  
Room Temperature - Filter Paper   acceptable   preferred for transport  
Refrigerated - Filter Paper not acceptable    
Frozen - Filter Paper  not acceptable  

 

Performed Test Frequency

Monday through Friday

Report Available

2 days

Additional Information

Drugs such as L-dopa, dopamine, epinephrine and norepinephrine are metabolized HVA and VMA and will fictitiously elevate their levels in the urine. Therefore, the patient should not be on such drugs when collecting the urine.

Methodology

Capillary Gas Chromatography/Mass Spectrometry

Performing Lab

Fairview U of MN

CPT

83150

84585

Interface Build Information

Result Code  Result Code Description 
2182 Homovanillic Acid Urine
4099 VMA (Vanillylmandelic Acid) Urine