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HelpTest ID LBOR0143 BCR::ABL1, Qualitative, Diagnostic Assay, Varies
Useful For
Initial diagnosis of BCR::ABL1-positive hematologic neoplasms (eg, chronic myeloid leukemia and acute lymphoblastic leukemia)
Detection and identification of BCR::ABL1 fusion forms, including the common p210 (e13/e14a2) and p190 (e1a2) forms, as well as other rare fusion forms
This test is not useful for therapeutic monitoring of patients with a known BCR::ABL1 fusion form.
Specimen Type
VariesOrdering Guidance
This test is qualitative only and should not be used for routine therapeutic measurable residual disease monitoring.
To monitor patients carrying BCR::ABL1 fusion forms coding for p190 (e1a2), order BA190 / BCR::ABL1, p190 mRNA Detection, Reverse Transcription-PCR (RT-PCR), Quantitative, Monitoring Assay, Varies.
To monitor patients carrying BCR::ABL1 fusion forms coding for p210 (e13/e14a2) protein, order BCRAB / BCR::ABL1, p210, mRNA Detection, Reverse Transcription-PCR (RT-PCR), Quantitative, Monitoring Chronic Myeloid Leukemia (CML), Varies.
To monitor patients carrying rare BCR::ABL1 fusion forms coding for e19a2, e13/e14a3, e1a3, e6a2, e19a3, e8a2, e12a2, e6a3, e8a3, and e12a3, order BARQ / BCR::ABL1, Rare Fusion Monitoring, Quantitative, Varies.
Shipping Instructions
Refrigerate specimens must arrive within 5 days of collection, and ambient specimens must arrive within 72 hours of collection. Collect and package specimens as close to shipping time as possible.
Necessary Information
Pertinent clinical history including the patient diagnosis of chronic myelogenous leukemia or other BCR::ABL1-positive neoplasm is required.
Specimen Required
Submit only 1 of the following specimens:
Specimen Type: Whole blood
Container/Tube:
Preferred: Lavender top (EDTA)
Acceptable: Yellow top (ACD)
Specimen Volume: 10 mL
Collection Instructions:
1. Invert several times to mix blood.
2. Send whole blood specimen in original tube. Do not aliquot.
3. Label specimen as whole blood.
Specimen Type: Bone marrow
Container/Tube:
Preferred: Lavender top (EDTA)
Acceptable: Yellow top (ACD)
Specimen Volume: 4 mL
Collection Instructions:
1. Invert several times to mix bone marrow.
2. Send bone marrow specimen in original tube. Do not aliquot.
3. Label specimen as bone marrow.
Reject Due To
| Gross hemolysis | Reject |
| Moderately to severely clotted | Reject |
Specimen Minimum Volume
Whole blood: 8 mL; Bone marrow: 2 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Varies | Refrigerated (preferred) | 5 days | PURPLE OR PINK TOP/EDTA |
| Ambient | 72 hours | PURPLE OR PINK TOP/EDTA |
Day(s) Performed
Monday through Saturday
Report Available
5 to 10 daysMethod Name
Reverse Transcription Polymerase Chain Reaction (RT-PCR) Multiplex PCR
Performing Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
81206
81207
81208
Reporting Name
BCR/ABL1, RNA-Qual, DiagnosticReference Values
A qualitative result is provided that indicates the presence or absence of BCR::ABL1 messenger RNA. When positive, the fusion variant is also reported.
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.Forms
1. Hematopathology Patient Information (T676)
2. If not ordering electronically, complete, print, and send a Hematopathology/Cytogenetics Test Request (T726) with the specimen.
Special Instructions
Secondary ID
89006SANFORD LABORATORY INTERFACE BUILD INFORMATION
| Result Code | Result Code Description |
|---|---|
| 20415 | Diagnostic BCR/ABL1 Result |
| 17482 | Specimen Type |
| 17483 | Interpretation |