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Test ID BLOD1789 Synthetic Glucocorticoid Screen, Serum

Useful For

Confirming the presence of listed synthetic glucocorticoids in serum specimens (see Interpretation)

 

Confirming the cause of glucocorticoid-induced adrenal insufficiency

 

This test is not useful for detection of fluticasone propionate.

Specimen Type

Serum


Ordering Guidance


 



Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 2 mL Serum

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Specimen Minimum Volume

Serum: 1.1 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Frozen (preferred) 14 days
  Refrigerated  7 days
  Ambient  24 hours

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Day(s) Performed

Wednesday

Report Available

5 to 14 days

Method Name

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

Synthetic Glucocorticoid Screen, S

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

80299

Reference Values

Negative

Cutoff concentrations

Betamethasone: 0.10 mcg/dL

Budesonide: 0.20 mcg/dL

Dexamethasone: 0.10 mcg/dL

Fludrocortisone: 0.10 mcg/dL

Megestrol acetate: 0.10 mcg/dL

Methylprednisolone: 0.10 mcg/dL

Prednisolone: 0.10 mcg/dL

Prednisone: 0.10 mcg/dL

Triamcinolone acetonide: 0.10 mcg/dL

 

Values for normal patients not taking these synthetic glucocorticoids should be less than the cutoff concentration (detection limit).

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.
Sanford Laboratories - Enterprise Additional Information:

SANFORD LABORATORY INTERFACE BUILD INFORMATION

 Result Code     Result Code Description   
 29495  BETAMETHASONE
 29496  BUDESONIDE
 29497  DEXAMETHASONE
 29498  FLUDROCORTISONE
 29499  MEGESTROL ACETATE
 29500  METHYLPREDNISOLONE   
 29501  PREDNISOLONE
 29502  PREDNISONE
 29503  TRIAMCINOLONE ACETONIDE